For humans living with diabetes: discussion, issues, and news.

cross-posted from: https://lazysoci.al/post/28370226

A team of biohackers with a wide geographic footprint, OIF is a non-profit focused on creating community-scale systems that can produce safe, affordable insulin.

See https://hackaday.com/2021/08/23/open-source-insulin-biohackers-aiming-for-distributed-production/

#diabetes #insulin #BigPharma #health

Abstract Magnesium (Mg2+) is an essential mineral for human health and plays an important role in the regulation of glucose homeostasis and insulin actions. Despite the widespread clinical evidences for the association of Mg2+ deficiency (MgD) and type 2 diabetes mellitus (T2D), molecular mechanisms by which Mg2+ contributes to insulin resistance (IR) are still under discussion. Mg2+ regulates electrical activity and insulin secretion in pancreatic beta-cells. Intracellular Mg2+ concentrations are critical for the phosphorylation of the insulin receptor and other downstream signal kinases of the target cells. Low Mg2+ levels result in a defective tyrosine kinase activity, post-receptor impairment in insulin action, altered cellular glucose transport, and decreased cellular glucose utilization, which promotes peripheral IR in T2D. MgD triggers chronic systemic inflammation that also potentiates IR. People with T2D may end up in a vicious circle in which MgD increases IR and IR causes MgD, that requires periodic monitoring of serum Mg2+ levels.

Nightscout (also known as "CGM in the Cloud") is an open-source cloud application used by people with diabetes to visualize, store and share the data from their Continuous Glucose Monitoring sensors in real-time. Once setup, Nightscout acts as a central repository of blood glucose and insulin dosing/treatment data for a single person, allowing you to view the CGM graph and treatment data anywhere using just a web browser connected to the internet.

There are several parts to this system. You need somewhere online to store/process/visualise this data (a Nightscout Site), something to upload CGM data to your Nightscout (a Master/Uploader), and then optionally you can use other devices to access/view this data (a Follower or usually several):