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One night of total sleep deprivation shown to have antidepressant effect for some people (medicalxpress.com)

submitted 2 years ago by [email protected] to c/[email protected]

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Major depression has previously been associated with abnormalities in REM sleep. Excess REM sleep would diminish noradrenaline, resulting in decreased binding to the ɑ-2 receptor in the medial frontal lobes comprised of the ACC and the medial prefrontal cortex. The absence of REM sleep with TSD may give some participants a break to improve top-down control of the amygdala, resulting in an antidepressant effect.

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[–] [email protected] 4 points 2 years ago

If i'm reading that correctly, it was one night of sleep deprivation followed by one night of good sleep.

I've always found that the night after an all-nigher I sleep really well and wake up feeling pretty rested and good, but interesting to see that apparently only happens for some people.