The trick is... you don't get the mastery.
I found another I found in a cellar that seemed impossible - there's a guy trying to absorb some creatures or something (hey, I wasn't paying attention!), but they only seem to spawn one after every wave, and the guy has to do some long animation thing after you get the creature to 20% health or so. I only managed to get 2 of 5 done by the time the timer ran out. Maybe it'll be easier if I ever see this event again at a higher level, but I've only seen it once so far since release.