this post was submitted on 14 Mar 2025
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I'd love to learn about the other factors. Can you illuminate a more correct understanding for me?
Pathophysiology and risk factors are actually a pretty much half of the curriculum for a separate medical specialty. Here are some resources for a different depth levels of this rabbit hole:
Basic level: https://www.cdc.gov/obesity/risk-factors/risk-factors.html
Moderate to deep:
Obesity Pillars journal (open access) https://www.sciencedirect.com/journal/obesity-pillars
decent book: Handbook of Obesity 4th edition Vol 1 by George A. Bray and Claude Bouchar, available free on Anna’s Archive or can be bought on Amazon
Too deep (mostly for medical professionals) and more expensive: Course of lectures at Columbia university: https://www.ihn.cuimc.columbia.edu/education/continuing-medical-education-cme/columbia-cornell-obesity-medicine
Thank you for the detailed reply.
The CDC link was brief as you indicated.
The CME lectures I can't afford.
I'll grab the handbook and look over it.
You are welcome. I liked the book and it has relatively recent info. Combining it with Obesity Pillars articles, you can get a very good understanding of modern views on pathophysiology of obesity.
I took a brief look over the handbook, every chapter, and especially the chapters on nutrition and metabolism
I think there are some major gaps that a more updated version of the handbook should cover, such as the previously mentioned carbohydate-insulin model of obesity https://hackertalks.com/post/7617450
If you have time I would highly recommend the ketogenic handbook: the science of therapeutic carbohydrate restriction - https://shop.elsevier.com/books/ketogenic/noakes/978-0-12-821617-0 - it is also available online at the usual places.
While the text isn't focused on obesity it makes a compelling through line between metabolic syndrome, hyperinsulinemia, and the conditions the obesity handbook has associated with obesity.
I did enjoy the opening quote about obesity: To treat obesity, Hippocrates, the “father of medicine,” suggested the following:
In this quote we have :