NonCredibleDefense

the ejection port is close to the shooter's face, making ambidextrous weapons nearly impossible

Keltec RDB

Keltec RFB

Springfield Hellion

DesertTech WLVRN

... I probably missed some, but there are many bullpup rifles that are swappable between left sided and right sided ejection ports, and swappable mag release, charging handle, bolt catch, safety selectors... or have some other solution to this problem.

Not exactly nearly impossible.

I would add in as a detriment of bullpups... that their internals are generally more complex, and properly identifying the cause of a failure to fire, and fixing it, while under stress, is often more difficult, and general maintenance tends toward being more time consuming as well.

Also: generally notorious for requiring a lot more foot lbs of force to pull the trigger, and that trigger pull is 'crunchier'.