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I can fuck up your vision through drugs, none of which actually affects the physiology in your eyes.

So? Thus? Therefore? I can fuck up your vision by poking out your eyes, none of which actually affects the physiology in your brain. Both of those are nonsense statements in the context of this discussion.

The brain is the one that transmogrifies the light and reassembles your world.

It's involved, but so are all parts of the eye and the visual nerve connecting them to the brain. I still fail to see how this is relevant.

It’s the brain that puts it all together. And that processing matters.

Not to (most) colour perception, that happens in the eyes and the visual nerve. For example our cone cells would be perfectly able to perceive ultraviolet light, but for most people it never reaches them because the lens of the eye filters that wavelength. There are people born without a lens, and they can indeed see ultraviolet light.

And glasses can’t help you. Even if you somehow fixed your cones to see colour, your brain would still be left in the dark. It’s… complicated. More complicated than putting a film over your eyes.

Well that might be true, if your entire premise wasn't wrong from the outset. You don't fix the cones, you fix the light. You take light of a wave length that would be indistinguishable to the cones, refract it, and then you have light of a wave length that is distinguishable by the cones. No brain or eye surgery necessary.

It’s a scam.

Enchroma? Yes. But not because they sell something that doesn't work, but because they sell something that does work for some colour blind people at inflated prices while lying about what it does exactly.