Duskers. A game that seems to be inspired heavily by the aesthetics of the first Alien movie. Instead of one terrifying xenomorph, there are four (?) different kinds all working independently to exterminate humanity. You're at the point in the story where they've basically succeeded, and you're trying to figure out what the heck happened. You get to do some basic scripting as well!

SpaceBourne 2

SpaceBourne 2 is a single-player, open-universe RPG and third-person shooter game with an abundance of features, including role-playing, mining, trading, piracy, crafting, and deep exploration. The story picks up where it left off in SpaceBourne, but now the player's goal is to build a new empire in the galaxy, with the methods of doing so being completely up to the player.

I know there has been some controversy around it, but Star Wars Outlaws might be worth a look.

star trek online. you could technically warp to destinations rather than fast travel but it would be hard to keep that up and ignore them. It even has a race event where the ships have to visit major planets and locations and it even allows for transwarps but because of the race nature you at best can use it for a shortcut or two to optimize the path. They used to have events with hourly rotations and just being up and watching the space map was sorta neat as you would see all these ships trying to do the race. They switched to a format where people could choose it more whenever they want though so it lost that particular community effect.

It's loosely in the same genre but you may like Rebel Galaxy. It takes a slightly different approach to space combat making it closer to naval warfare. Very enjoyable soundtrack.

Haven't seen anyone mention Starpoint Gemini. Warlords was probably the best iteration. Kinda like Eve but single player and a half way decent story.

Not really what is looked for here in most ways, but there's Parkan.

I have little to say other than it exists.

I'm commenting late, but there is The Precursors which does require Slavjank tolerance, but if you have it, it provides an interesting flavor on a space opera adventure.

I also haven't tried The Tomorrow War which seemingly requires even higher Slavjank tolerance, and probably isn't a top of all time game, but seems interesting if you like peering into strange forgotten games. Warlockracy did a video of this one.