The thrill of flying a 747 in flight simulator quickly wears off when you realise large planes are really fucking dull.
After takeoff you turn on autopilot and there's fuck all to do for the next few hours apart from occasionally twisting the heading knob, or setting up the ILS approach for the landing.
It may actually liven the experience up if you have to deal with passenger complaints when you mistakenly over prescribe alcohol. You need to give the passengers enough to get them lethargic but not so much they reach the angry or depressed stage.