Gaming

Mirror's Edge is a good one I haven't seen mentioned yet. A bit older by this point but it was a fun one.
Transistor is another great one. The gameplay was fine but the art and sound is incredible.

technically any MMO (or other RPG) that lets you build a female character, but I would say FFXIV as there are a lot of interesting female secondary protags.

Hmm, by that standard, Pathfinder: Kingmaker and Pathfinder: Wrath of the Righteous both qualify, though opinions on the NPC companions vary.

Nier: Automata

Immortals: Fenyx Rising

A couple of the Star Ocean games let you choose between a Male or Female protag.

I'm having a great time finally getting into What Remains of Edith Finch.

Control is excellent

Not female, but the protagonist of Outer Wilds is nonbinary, as is their entire species.

There's Alien: Isolation if you're looking for a horror game. Every so often I'll go and give it another playthrough. That game was phenomenal, especially if you're a fan of the Alien movies

Assassin's Creed Odyssey female lead is canon, although you have the choice to play the male as well.

Can I suggest some great novel games?

**VA-11 HALL-A: Cyberpunk Bartender Action **

• play as a bartender and change outcomes of stories by providing different drinks

Fatal Twelve

• death game, mystery, lesbian couple as main character, one of the best

I enjoyed Uncharted: The Lost Legacy. It's a bit shorter than U4, but still worth playing. I liked Chloe and Nadine together.

Trying to find some that haven't been talked about yet:

Echo. It's a fantastic experimental infiltration game with an AI that adapts to your way of playing. The setup is very impressive.

Pathologic: one of the three playable characters (the Changeling). It's a bizarre russian game, with an unique world, and messy gameplay. Can't recommend it enough.

Va11 Hall-A: chill bartending game in a cyberpunk setup.

The Blackwell series: comfy, kind of amateurish point and clicks by Wadjet Eye. I like them very much.

Transistor: weirdest game by Supergiant. You play as a redhead with a talking sword. I don't remember much about it except that it was good.

The Fall: (pushing it a little bit, since the protagonist is an AI, but I've always seen here as female.) Criminally underrated puzzle games, disguised as metroidvanias.

Eliza (by Zachtronics): the only visual novel I enjoyed. It's hard to explain, it's about AI, burnout, whether tech dehumanizes people, and solitaire.

Hedon Duology: for something completely different, it's a slightly kinky retroshooter, with amazon Orcs fighting demons.
It may sound a bit dumb, but it's excellent. Huge levels, interesting worldbuilding, and a gameplay based on exploration, puzzles as well as shooting.

There's probably a ton more, but that's all I can think about at the moment.

Don't see it mentioned yet, it's an older game but Remember Me is pretty good

Ms Pac Man obviously

Silent Hill 3 has a great female protagonist imo, but you have to play Silent Hill 1 to get the gist of the story in 3.

Great list from @[email protected], just a few more:
Gris is an absolute gem.
The A Plague Tale duology is also up there (with Requiem being my favourite game of all time, so I'm extremely biased, sorry / not sorry :D).

Cyberpunk!

Jade from Beyond Good and Evil.

Returnal is a great game if you like roguelite mechanics. Great gameplay, art design, and sound. The haptics on the PS5 are excellent too.

I just started playing Asscreed Odyssey last week, having fun so far. A bit of a departure for the series, more of a Witcher-style open world action-adventure game in ancient Greece. You can select between player characters Alexios (male) and Kassandra (female), I picked Kassandra, I like her, she seems decently written and the voice acting is great.

Elden Ring is incredible, although it's silent protagonist (aside from grunts etc), and might be too difficult. I know many women who love it though.

CrossCode is an excellent neo-retro overhead 2D action RPG. Great combat system, puzzles, and story.

Valheim isn't very story heavy but it's an incredible exploration/survival/crafting game, one of my all time favourites.

Steve Jackson's Sorcery! Parts 1 & 2 (and sequels Part 3 and Part 4): Masterfully crafted interactive "choose your own adventure" videogame, pretty much a video-book with an immersive story and wonderful illustrations. Highly recommended, I've been enjoying Jerma985's streams of it. You're constantly making choices that will completely change the outcome of the game, there is a rewind button if you need it.

Control has already been mentioned by others, I also recommend it. Great writing, graphics, lots of humour in the environment. Especially if you're a fan of SCP. Honestly the combat got a little monotonous towards the end but it didn't overstay its welcome. The documents you find around the world are hilarious and well worth a read.

It's older, but The Longest Journey is good. Unfortunately, the final game in the series kinda sucks.

While it's an ensemble, most people would agree that the main character of Final Fantasy VI is a woman—they just might disagree about which woman is the lead.

I also liked the first Xenosaga game, but again, it's a series that goes pretty badly downhill.

Aquaria

A very well put together Metroidvania. The map is very fun to explore, good boss fights, great music, and interesting story.

Plague Tale:Innocence and Requiem

Night in the Woods is objectively the best game ever made by any measure. Tacoma and Gone Home are amazing too.

I mean I dunno, it depends on what kind of games you like, surely?

Resident Evil Remake 2 and 3, great games with both male and female protagonists!

Surprised no one has mentioned Tomb Raider yet. Others not yet mentioned:

• Assassin's Creed: Liberation, and Chronicles: China
• Beyond: Two Souls
• The Last of Us Part II
• inFamous: First Light

A group of developers have created a version of the game and it's sequels that runs on modern machines: http://nolfrevival.tk/

Edit: this was meant as a reply to @KIM_JING_JUICEBOX 's comment. No One Lives Forever is a whip smart spy FPS that nails the Bond aesthetic but stars an unforgettable female protagonist, Kate Archer. Download it for free above.

If you're into the anime aesthetic: Nier Automata, Atelier series, and Recettear. I think FFXIII is fun but people would argue otherwise.

Going Under. It's a goofy rougelike game which parodizes corporate companies and startups. You play as an unpaid marketing intern who needs to kill monsters from failed startups, but she applied for marketing,

Most games I can think of have been mentioned, but I found Signalis to be an interesting experience assuming you can get past the annoying inventory management

Whoa whoa whats wrong with Senua?