Essentially, yeah. Most programs will install to your root directory, but all your personal configs and personal files will be in your home directory.
What I'd personally recommend is using Timeshift to automatically keep backups if your home directory on a separate partition, then if you want to switch distros or if you need to reinstall for whatever reason you can use Timeshift to restore your home directory pretty easily, as long as your new install uses the same file system.
Bitwig and Blender work great on Linux, as well as most games. MS Office and the proprietary apps will need a separate Windows install. Wine is a compatibility layer that essentially translates the Windows files into something that your Linux OS can use. It works great for some things, like games, but isnt recommended/doesn't work for others, like Office or Adobe suite. Personally I'd recommend finding the alternatives for the programs you need on Windows and trying them out, while keeping the original programs in your Windows install. You can get used to the workflow of the new programs and decide if switching is a viable thing for you. And if not, hey now you're comfortable with another set of programs just in case you need them in the future.