I do! I was developing pretty bad RSI from my traditional keyboard/mouse setup so I got:
- An Evoluent Vertical Mouse D: https://evoluent.com/products/vmdm/
- A Kinesis Advantage 2 (which I recall you and I have talked about a bit before): https://kinesis-ergo.com/shop/advantage2/
For me, the keyboard was the fix for my wrists. The vertical mouse didn't help at all and was much more frustrating to use than my Deathadder because clicking now jiggles the cursor a bit (because the force of the click is now sideways, rather than down into the desk). However, it did help a lot when I started getting elbow pain from the regular mouse. Of course, I later discovered that it was just transferring the strain from my elbow up to my shoulder, once that started to hurt...
Nowadays I'm just back on my exercise plan, and nothing hurts anymore π Obviously working out won't fix wrists though. If I recall right you're using Colemak on a regular board for your wrists? May be time to try the "full swoop" or whatever the style of the Kinesis is called. Or if I misremember and you're already using an ergo board, I hope the vertical mouse helps!
Honestly, my only issue was the lateral force of a click jiggling the cursor, but that can be sort of compensated for using the thumb to brace the mouse. Actually moving it around was fine, it's not too heavy, it positively glides across my mousepad. But check the sizing guide; they are indeed bulky compared to a normal mouse as you note. I don't think the bulk affects the comfort at all though, for me anyway.