wjs018

joined 2 years ago
[–] [email protected] 2 points 2 years ago

The fact that they are devoting two hours to tell the first part of the story gives me a lot of confidence that they are taking the time to tell the story in a deliberate way. I have written elsewhere that this series really reminds me of Mushishi and everything I liked about that show, so I am super excited that they seem to be giving it the pacing that it needs to help the story hit.

[–] [email protected] 2 points 2 years ago

I have read the manga and the early manga definitely gives me Kino's Journey/Mushishi vibes. Those are two of my all-time favorite anime and Frieren is probably the closest I have ever come to having that same feeling in manga form. So, I am super excited about it as well.

[–] [email protected] 21 points 2 years ago

The type of pill that was approved is the progestin-only "mini pill" which has a much safer clinical profile than the more common-in-the-US combination pill that has both progestin and estrogen. This type of pill is already available OTC in over 100 other countries. The US is just really behind the curve on just about anything to do with reproductive rights and care.

 

cross-posted from: https://mander.xyz/post/1133527

Paywall-free link: http://archive.today/oPjro

[–] [email protected] 2 points 2 years ago* (last edited 2 years ago) (1 children)

I don't think they have given a complete list of what will be included. For the first two episodes it is as follows based on a quick scan of the manga. I don't really have the time to go through the whole first season, but as you can see from episode 1, they are likely to jump around a bit.

Episode Manga Chapters
Episode 1 6, 40
Episode 2 47-50

Edit: I did go back through some of the first season, but I ran out of time, so here is the first half the season (roughly):

Episode Manga Chapters
Episode 1 1-3
Episode 2 4, 7, 9
Episode 3 10-13
Episode 4 16-20
Episode 5 21-24
Episode 6 26-27, 29-30
Episode 7 34-37
[–] [email protected] 2 points 2 years ago

So far this season...

Enjoying:

  • Horimiya
  • Zom 100

Waiting to see how it plays out:

  • Vending machine
  • Ryza
  • One Room Hero
  • Helck

Waiting to binge after the season is over:

  • Kenshin

Old show I am currently watching:

  • Science Fell in Love
[–] [email protected] 1 points 2 years ago

I don't blame you for dropping Ryza. I am going to give it one more episode before dropping since I have heard good things about the source from a friend that is excited about it, but so far I have found it very dull.

[–] [email protected] 3 points 2 years ago

Username checks out!

 

Breakthrough here is the ability to image embryos comprised of living cells as opposed to post-mortem embryos.

original doi: https://doi.org/10.1016/j.cell.2023.06.003

 

This piece resonated with me as I also did not really envision myself working in industry when I started grad school; figuring that I would just stay in academia in one form or another. However, when I started to look outside academia (after seeing lab mates stuck in endless post-doc loops), I was surprised at the breadth of opportunities that were available.

Even though my degree was in physics, I was doing stuff relevant to several different industries. I interviewed for roles in data science, materials science, petrochemicals, food science, and pharma. Ultimately, I ended up in pharma and the very first program I worked on was an immunotherapy to target the type of cancer that caused the death of my grandfather. It wasn't some grand design on my part, just a coincidence that echoes some of what this author experienced.

 

The issue seems to be how the data was collected in the Phase 3 trial:

Clinical trials of most drugs and vaccines supporting FDA approval are mainly conducted in the U.S. and Europe, where clinical trial protocols are well recognized. The phase 3 TIDES trial used for Qdenga’s application was run in several less well-off, dengue-endemic regions in Latin America and Southeast Asia.

However, it should be noted that Takeda's drug, Qdenga, is already approved by the EMA in the EU and a couple other agencies. It is just the FDA that is holding things up in the US.

[–] [email protected] 6 points 2 years ago

Yeah, even comments here haven't seemed to read the article. As somebody that used to install BOINC on all my machines back in the day, the reason I stopped is that many of the projects I ran (SETI being one) aren't active any longer. Also, like the article mentioned, I just don't have a desktop anymore and I am not about to run something like this on a laptop that doesn't have things like user-serviceable or replaceable parts.

[–] [email protected] 2 points 2 years ago

I think that @[email protected] provided a great response for the specific case of flow in a pipe.

I just want to add that if you look beyond the restrictions of flow in a pipe, there are many other types of behavior that non-Newtonian fluids exhibit. We measure this in the lab on instruments called rheometers. Basically, we put some liquid in the instrument and then deform it and measure the resistance to that deformation. One of the most common ways to apply that deformation is to do so back and forth in an oscillating manner. Depending on the frequency at which you apply this strain, the solid/liquid-like behavior can change. If you have some background in physics or want to get a decent understanding, I found this paper that, on skimming it, seems to be pretty consistent with the way I was taught this stuff in grad school.

One graph I want to point out is Figure 13 which shows what would be a "typical" viscoelastic polymer solution. An easy way to understand this graph is that as we go from left to right, we are applying strain back and forth quicker and quicker, essentially shaking it faster. When the G' value is higher than the G" value, then the material is behaving more like a solid and conversely, when G" > G', then it is behaving more like a liquid. You can see that the material goes through different phases of behavior as the strain frequency changes. Just for you I went and dug up an old graph from my thesis to show a real-life example of this happening too.

My favorite demonstration of this is to put Oobleck (or something similar) onto a speaker and then change the frequency and see what happens.

[–] [email protected] 1 points 2 years ago

Please, please let Ooyama's accidental confession mean something. Imo, this series has really pushed the "do they like me" bit to the breaking point. If Akutsu goes back to questioning it, then it's clear this series is never going to see real relationship progress.

 

Continued fallout from the explosion of the Centaur upper stage on ULA's test stand as Vulcan's launch continues to slip.

In a statement, ULA described the work needed on the Centaur V upper stage as “minor reinforcement at the top of the forward dome,” or the uppermost section of the liquid hydrogen tank. The changes will add strength to the tank, which contains super-flammable fuel chilled to minus 423° Fahrenheit (minus 253° Celsius).

The pressure is on as the DOD is eagerly waiting for Vulcan.

The US Space Force is eager for the Vulcan rocket to enter service. The Pentagon selected ULA and SpaceX in 2020 to launch around 40 of the military’s most critical surveillance, communications, and navigation satellites from 2022 through 2028. ULA won the rights to launch about 60 percent of the missions, primarily using the new Vulcan rocket, with SpaceX taking the remaining 40 percent with its Falcon rocket family.

 

"The postponement is motivated by obligatory compliance with the prevention of forest fires... as well as the high temperatures" in southern Spain "to ensure the safety of the area where the launch is carried out".

First time I have seen this cited as a reason for a launch delay.

 

This is about a recent study looking at the rheology of fondant. Essentially, fondant is created from a supersaturated solution of sucrose that is agitated (kneaded). This causes the fondant to experience a sequence of events:

  1. First, the agitation induces crystal nucleation and growth. In the early stages of crystal formation, the surrounding solution is depleted of sucrose, reducing the bulk viscosity.
  2. However, as the crystals grow in size, they are large enough to push against one another in hard sphere-like interactions. This causes a sharp increase in viscosity at this critical crystal size.
  3. As agitation continues, sucrose crystals fracture and the system reaches an equilibrium crystal size distribution, causing the viscosity to decrease from its peak. This is the final state of a smooth, pliable fondant.

There is a doi provided by the article, but as of my posting this, the doi hasn't been activated yet.

[–] [email protected] 2 points 2 years ago (1 children)

Agree that the ending felt a bit weak. I think that picking up the pace in the show a bit more and getting further in the story would have helped things. At the moment, Raeliana is still a character without much agency, and it would be great to see a bit of her future character growth.

[–] [email protected] 2 points 2 years ago (1 children)

So, it has been a while since I read the manhwa (I haven't read the original webnovel), but I am overall pleased with how the adaptation has gone so far. You could definitely tell that there were very limited budgets. There are so many instances of slideshow animations or just still images, but they seemed to invest heavily in making beautiful stills and backgrounds.

My major complaint about the show is that, in general, it has gone very slowly. I expected them to be further along in the story after 12 episodes, but the pacing has been plodding at best. If my memory serves, I think they adapted 3 of the 7 volumes of the manhwa. I understand that a lot of shows tend to go too quickly, but this show just seems to drag out every conversation like it is padding for time (maybe to help stretch the animation budget too).

Overall happy with the show so far and hope that if it gets a second season it gets a bit more resources thrown its way.

 

This is a summary of a Phase 1/2 trial of a cell therapy meant to stimulate insulin production in diabetes patients. The top line is that it met its clinical endpoints and several of the patients no longer require external insulin dosing at all and their blood sugar is well managed. Vertex also has a number of follow-up therapies in the pipeline meant to improve upon this therapy.

I personally don't have much experience in cell therapy, but the potential of a treatment like this is clear. We will see what the data looks like as this goes through the clinical trial pipeline and expands the patient population in Phase 3.

 

Not sure if TIL-type posts are allowed here, but thought that the story of the history of this event is interesting in a "history of science" type of way. If you want a narrative style of telling, you can check out this Smithsonian piece.

Story time! I watched Jurassic Park again recently and there is a bit in the movie where there is a discussion about competing theories for how the dinosaurs met their end. I didn't realize that back in the early 90's the impact theory was just one of a competing number of theories, so I did some reading.

Turns out that while doing readings to explore for gas/oil in the Caribbean, the Mexican state oil company, Pemex, had found evidence for the Chicxulub crater way back in the 1940's, but dismissed it as volcanic activity and moved on since volcanic regions are not great for oil extraction.

Fast forward to the late 70's and geophysicists are making additional measurements for Pemex and correctly ID the ring structure of these readings as a likely impact crater. The company is not really interested but consent to allow them to present their findings.

The cruel irony is that the conference at which the findings were presented occurred the same week that there was a special, separate conference with impact crater experts to discuss the impact theory of the end of the dinosaurs. So, there were no experts in attendance to learn about Chicxulub crater's existence from the Pemex scientists or recognize it's importance.

It took another 9 years, 1990, before the two worlds connected and further action was taken to ID Chicxulub as the impact crater that corresponded to the exact time period scientists were looking for.

Then, finally, it was 2010 before scientific consensus was (generally) reached that Chicxulub is the impact that ended the dinosaurs.

 

doi for the original Science piece: https://doi.org/10.1126/science.adh3104

 

cross-posted from: https://beehaw.org/post/720520

This summarizes a report from Parks Canada about the reintroduction of bison to the Banff National Park.

A Parks Canada report published this week concluded that the reintroduction was a success, and it suggested that due to their robust growth rate, this bison subpopulation—one of only five that occupy a mere 0.5 percent of their original range in North America—may no longer be considered endangered within a decade.

Original report: https://parks.canada.ca/pn-np/ab/banff/info/gestion-management/bison/rapport-mai-reintroduction-may-report

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