Science Memes

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It's a tradeoff (lemmy.world)

submitted 2 months ago by [email protected] to c/[email protected]

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[–] [email protected] 10 points 2 months ago (3 children)

For the curious: https://www.nejm.org/doi/10.1056/NEJMoa072464?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0www.ncbi.nlm.nih.gov

[–] [email protected] 9 points 2 months ago (2 children)

ELI5

[–] Kalothar 10 points 2 months ago

Basically this mutation is shown to protect against malaria, but it causes an issue with producing a molecule needed for the creation of ATP (energy your body needs)

So while they can offer a protective effect to the subject they could need transfusions or other treatment to stay healthy.

Subject 1 & 2 had similar biomarkers, and subject 3 had different markers causing a type of misread that made them transfusion dependent.

That’s my understanding at least

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