Oh, we’re not resistant, we’re just crazy enough to like the pain. Birds are resistant and don’t feel it at all, they can eat chilis like fruits.

There's a book called The Botany of Desire, by Michael Pollan, which is about this. Looking from the plants eye view of things, they have manipulated us into growing them in a huge variety of environments. The book focuses on tulips, cannabis, apples, and potatoes, iirc. Fascinating book.

Two quick examples from the book:

Pot gets us high, now we grow it in closets, warehouses, yards, basements, attics, etc.

Apples don't reproduce true from seed, so Johnny Appleseed brought readily available cider to the Americas. (You need a cutting of an apple tree to grow that type of apple.)