When researchers say "observe" they actually mean "measure". And when you're working with sub-atomic particles, "measure" isn't some passive activity. It's an active thing. When you measure small particles you are applying some force upon them, changing them in some way from how they would otherwise act.

Imagine if you were tasked with measuring traffic on the other side of the planet, but you had no cameras. The only tool you had was a gigantic 30 ton, satellite-networked pendulum swinging across the highway. The only way you know if there are cars on the highway is if the pendulum thwacks into one of them. That's quantum particle physics.... I think.