It sounds silly, but this is literally the basis for most research. Ask a seemingly simple question you don't know the answer to, quickly realize that it's a lot more complicated than it sounds, search journals for existing research in the area and find it lacking, write up a proposal and convince someone to fund you, do a lot of experiments, and if you don't go crazy or run out of funding, write a paper about it and submit it to journals for peer review.
I wish you good luck!